Ovulation induction and (COH)
Ovulation induction and controlled ovarian hyperstimulation (COH)
Ovulation induction is the action of bringing about ovulation through oral (Letrozole, Clomiphene Citrate, Tamoxifen) or injectable (gonadotropins) hormonal medication.
This process is used in female patients who have irregular (oligo-ovulation) or absent (anovulation) menstrual cycles. Causes vary and include dysfunction of the hypothalamic-pituitary-ovarian axis, anomalies in thyroid hormone or prolactin secretion, and hyperandrogenism, most commonly as a result of the polycystic ovarian syndrome.
Ovulation induction is usually achieved by the administration of oral or injectable medications and can be monitored at home through basal body temperature curves and cervical mucous observation, or in the clinic by the use of hormonal blood tests and pelvic ultrasounds.
Ovulation induction can be coupled with intra-uterine insemination (IUI) in case of presence of male factor infertility.
Controlled ovarian hyperstimulation (COH)
Controlled ovarian hyperstimulation (COH) involves the use of oral or injectable medication to achieve ovulation of 1 or more than 1 egg in a single menstrual cycle with the purpose of increasing the chances of achieving a pregnancy.
COH is usually used in couples with unexplained infertility, or in mild male factors in combination with IUI.
The risks of ovulation induction and COH include multiple pregnancy and the possible side effects of the medication used.
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